The correlation between FDG uptake and various oncogenes expression in pancreas cancer

我们研究了胰腺癌中FDG摄取指数（SUVmax）、MRI弥散指数（ADC）和各种癌基因表达之间的相关性。SUVmax与EGFR、Ki-67、CDH 13、VEGFA、p53呈弱正相关，复发组SUVmax明显高于无复发组。复发组ADC值明显低于复发组。CDH 13和VEGFA在复发组中的表达均显著高于正常对照组，肿瘤血管增生和组织粘连等基因表达是胰腺癌的重要预后因素，SUVmax和ADC均值是预测胰腺癌预后的重要影像学指标。

We examined correlation among FDG uptake indices (SUVmax), MRI diffusion index(ADC) and various oncogenes expression in pancreas cancer. In addition, we evaluated the association those parameters and prognoses.Positive weak correlations were noted among SUVmax and EGFR, Ki-67, CDH13, VEGFA, p53.The value of SUV max was significantly higher in the recurrent group compared with that of the non-recurrence group. As for ADC mean level, it was significantly lower in the recurrent group. Both CDH13 and VEGFA demonstrated significantly higher values in the recurrent group.In pancreas cancer, gene expressions such as involving in tumor-vascular proliferation and tissue adhesion were the important prognostic factor.In addition, both SUV max and ADC mean were important imaging biomarker for predicting prognosis.