Development of a high-speed energy-dispersive X-ray computed tomography system and its application to molecular-level imaging

在本研究中，我们开发了一套能量色散X射线计算机层析成像(ED-CT)系统，该系统使用25 mm/S线阵CdTe扫描仪、转台和X射线发生器。使用该ED-CT，最大计数速率为亚MCPS，使用碘和Gd对比剂进行K-Edge增强成像，在高对比度下观察血管和癌变区域。将镉镉探测器与x-y工作台相结合，我们还研制了透射型相机、反射型荧光相机和背向散射X射线相机。为了实现MCPS距离成像，我们研制了LSO-MPPC和YAP(Ce)-MPPC探测器。使用这两个探测器，我们构建了ED-CT系统，并进行了高速K边缘成像。最近，开发了一种双能量比较器，并利用同时获得的两个不同的能量图像进行了双能量减法。

In the present research, we developed an energy-dispersive X-ray computed tomography (ED-CT) system using a 25 mm/s linear CdTe scanner, a turntable, and an X-ray generator. Using this ED-CT with a maximum count rate of sub-Mcps, we performed enhanced K-edge imaging using iodine and gadolinium contrast media, and blood vessels and cancerous regions were observed at high contrast. Using the CdTe detector in conjunction with an x-y stage, we also developed a transmission-type camera, a reflection-type fluorescence camera, and a back-scattering X-ray camera. To carry out Mcps-range imaging, we developed LSO-MPPC and YAP(Ce)-MPPC detectors. Using these two detectors, we constructed the ED-CT system and performed high-speed K-edge imaging. Lately, a dual-energy comparator device was developed, and dual-energy subtraction was performed using two different energy images which were obtained simultaneously.