The evaluation of sepsis by new endotoxin detection methods

激光散射光度法（ESP）检测内毒素的灵敏度高于普通浊度法。与普通方法相比，ESP对有无感染性休克和脓毒症患者有明显的鉴别作用。ESP与降钙素原试验的预测能力无显著差异，降钙素原试验是诊断细菌感染的常用工具之一。内毒素吸附疗法（PMX）改善了腹腔感染感染性休克患者的临床情况，降低了ESP法测定的血浆内毒素。我们还观察到，即使PMX持续时间较长，ESP法通过柱后内毒素也有所减少。

Endotoxin Laser Scattering Photometry (ESP) method may more sensitively detect endotoxins than the ordinary turbidimetric method. ESP significantly discriminated between patients with or without septic shock and sepsis compared to the ordinary method. There was no significant difference in predictive power between ESP and procalcitonin test that is one of common tools for the diagnosis of bacterial infection. The patients clinical conditions of septic shock due to intra-abdominal infection were improved by endotoxin adsorption therapy (PMX), reducing plasma endotoxins measured by ESP method. We also observed the reduction in the endotoxin after passing through column by ESP method even after the longer duration of PMX.