Role of RAGE in peri-operative lung injury

研究了晚期糖基化终末产物受体(RAGE)在人肺组织中的表达。慢性阻塞性肺疾病(COPD)患者肺泡I型细胞和肺泡巨噬细胞表达增加。表达与1秒用力呼气量呈负相关。愤怒情绪表达与吸烟指数无关。在肺癌中，RAGE在小细胞肺癌和腺癌中均有高表达。低分化腺癌表达RAGE的频率高于高分化腺癌。RAGE在非粘液性腺癌中表达增强。晚期腺癌RAGE表达分值较高。RAGE的表达与AGEs呈负相关，但与HMGB-1、S100A4的表达无相关性。在大鼠肺内，PPAR-γ可能通过阿米洛利敏感的钠通道损害肺泡液清除。

The expression of receptor for advanced glycation end products (RAGE) was examined in the excised human lungs. The expression of type 1 alveolar cells and alveolar macrophage increased in chronic obstructive pulmonary disease (COPD). The expression was correlated negatively with forced expiratory volume in one second. RAGE expression was not associated with smoking index. In lung cancer, RAGE was highly expressed in both small cell lung cancer and adenocarcinoma. Less differentiated adenocarcinoma expressed RAGE more frequently than well differentiated adenocarcinoma. The enhanced expression of RAGE was present in non-mucinous adenocarcinoma. Adenocarcinoma in the advanced stages tended to show a higher expression score for RAGE. The expression of RAGE inversely correlated with that of AGEs, although it did not show any relationship with the expression of HMGB-1 or S100A4. In rat lung, PPAR-gamma impaired alveolar fluid clearance probably through amiloride-sensitive sodium channel.