Basic and clinical aspects of LUTS induced by cold stress

冷应激引起的下尿路症状（LUTS）尚未得到充分研究。分析了LUTS/良性前列腺梗阻患者膀胱粘膜中的自主神经系统受体mRNA。膀胱粘膜中α 1 d AR、β 3 AR、5-羟色胺2b、3a、7 mRNA表达增加。5-羟色胺机制可能在冷应激引起的下尿路症状中起作用。50人参加了公共卫生管理研讨会进行了研究。根据自我描述的冷应激敏感性，将参与者分为冷敏感组和非冷敏感组。日常锻炼和生活方式的改变对冷敏感人群的LUTS有效。对便秘或冷敏感的便秘性LUTS患者给予药物级日本传统药物大研中托。Daikenchuto改善了LUTS，表明这是便秘或冷敏感性改善的结果。

Lower urinary tract symptoms(LUTS) induced by cold stress has not been sufficiently studied. Autonomic nervous system receptors mRNA were analyzed in bladder mucosa of patients with LUTS/benign prostatic obstruction. There was an increased expression of alpha 1d-AR, beta 3 AR, serotonin 2b, 3a, 7 mRNA in the bladder mucosa. Serotonin mechanism may take a role in LUTS induced by cold stress. 50 people who visited a public health management seminar were studied. The participants were devided into two groups-cold sensitive and non-sensitive- according to self-described sensitivity to cold stress. Daily exercise and lifestyle modification was effective for LUTS in cold sensitive people. Daikenchuto, a pharmaceutical-grade traditional Japanese medicine, were administered to the refratory LUTS patients with constipation or cold sensitivity. Daikenchuto improved LUTS suggesting as a consequence of improvement of constipation or cold sensitivity.