Study of susceptible gene for optic neuritis

为探讨视神经炎的易感基因，我们收集了73例视神经炎患者的临床资料和DNA样本。我们用DNA微阵列(Axiom Genome-wide Human DNA芯片)检测了51例患者的SNP类型，并与419名健康志愿者的SNP数据进行了全基因组关联分析。因此，我们在第2染色体短臂区域(C2orf61)、第4染色体短臂区域(RAB28，KCNIP4)、第9染色体短臂区域(GLDC，HAUS6，FAM154A)、第16染色体短臂区域(CBLN1)和第17染色体短臂区域(CACNG4)附近发现了几个与视神经炎有微弱关联的候选基因。

To examine the susceptible gene for optic neuritis, we collected the clinical data and DNA samples from 73 cases with optic neuritis. We examined SNP types using DNA microarray (Axiom Genome-Wide Human DNA Array) in 51 cases and performed genome wide association analysis to compare with the SNP data of 419 healthy volunteers. Consequently, we found several candidates genes for optic neuritis near the region of short arm in chromosome 2 (C2orf61), short arm in chromosome 4 (RAB28, KCNIP4), short arm in chromosome 9 (GLDC, HAUS6, FAM154A), long arm in chromosome 16 (CBLN1) and short arm in chromosome 17 (CACNG4), that have weak association for optic neuritis.