Research for genes associated with glaucoma

为了确定正常眼压性青光眼（NTG）的易感基因，我们收集了600多名日本NTG患者的血液样本并提取DNA。我们使用280例NTG患者和560例健康对照作为第一次筛选，使用DNA微阵列进行全基因组关联研究。此外，使用独立病例和对照集进行第二次筛选和重复研究。结果发现一个与NTG易感性密切相关的基因位点。

To identify the susceptible genes for normal tension glaucoma (NTG), we collected blood samples from more than 600 Japanese patients with NTG and extracted DNA. We performed genome-wide association study with DNA microarray using 280 samples from NTG patients and 560 healthy controls as the 1st screening. Moreover, the 2nd screening and replication study were performed using the indipendent case and control sets. As the results, we found a gene locus that might be closely associated with the susceptibility of NTG.