Comprehensive analysis of functional monomer in dental adhesives using molecular-level analysis technique and investigation of the most suitable composition of adhesives

据报道，10-MDP在应用时促进了树脂-羟基磷灰石界面自组装层的形成。 首先，本研究表明，基于10-MDP的商业粘合剂也形成了两个10-MDP分子的自组装分层，通过稳定的MDP-Ca盐形成，在人牙本质和树脂之间的界面处，类似于10-MDP溶液。用FIB-SEM进行的三维观察表明，MDP-Ca盐在界面处形成，延伸到粘合剂（树脂）层中。 以MDP-Ca盐为粘结层模型制备了粘结剂，并对其性能进行了测试，结果表明，加入MDP-Ca盐后，聚合收缩率降低，部分性能提高。得出结论，含MDP的粘合剂确实在粘合剂界面处形成纳米分层，并且MDP-Ca盐通过粘合剂层扩散。粘结剂层的性质与树脂、盐和其他残留牙体物质有关，可能影响粘结力。

It was reported that 10-MDP promoted formation of self-assembled layering at resin- hydroxyapatite interface when it was applied. Firstly, this study showed that the commercial 10-MDP based adhesives also formed the self-assembled layering of two 10-MDP molecules, joined by stable MDP-Ca salt formation, at the interface between human dentin and resin as similar to 10-MDP solution. The three-dimensional observation with FIB-SEM revealed that MDP-Ca salt was formed at the interface, extending into the adhesive (resin) layer. When we prepared adhesives containing MDP-Ca salts as a model of adhesion layer and measured its properties, polymerization shrinkage decreased and some of properties increased by adding the salt. It is concluded that MDP-containing adhesives do form nano-layering at the adhesive interface and MDP-Ca salt spread through the adhesive layer. The properties of adhesive layer with resin, salts and other residual tooth substances may influence the adhesion.