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Osmotic fragility of erythrocyte membrane caused by the change of Band 3

Osmotic fragility of erythrocyte membrane caused by the change of Band 3
Band 3变化引起的红细胞膜渗透脆性
批准号:
23650407
负责人:
KANAO Yoji
金额:
$1.08万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
翻译
本研究的目的是通过组成脆性红细胞的蛋白质的差异来阐明脆性红细胞与非脆性红细胞的区别。在SDS-PAGE分析中,在坚韧的红细胞中发现了较厚的120、80、66、60、(KDa)四条带。经LC-MS/MS分析,确定为锚定苷。因此,这一结果表明,由于部分锚蛋白的丢失,红细胞膜是脆弱的。
英文摘要
The purpose of this study is to clarify the differences between fragile red cells and not fragile ones through the differences of proteins which compose those red cell. In the analysis of SDS-PAGE , thick bands are found in tough red cells in four bands such as 120 ,80 , 66 , 60 , (kDa). Under the analysis of LC-MS/MS , ankyrin is clearly found . Thus that result suggests that the red cell membrane is fragile due to loss of a part of ankyrin.
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