Stochastic Modelling of Genetic Regulatory Networks: Subtitle - Genetic Regulation is a Noisy Business

人类基因组的完成标志着100年来细胞生物学中还原论科学的高潮。尽管进一步的生物信息学分析将继续进行，但重点正在转向合成和理解调控遗传成分如何动态相互作用以形成功能表型。关键是要理解细胞过程中随机性的作用。该项目将探索这些角色，并将开发一个集成的复杂系统建模、仿真和可视化框架。这将用于造血谱系承诺的范例应用，并用于探索和验证一般的遗传调控模型。

The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will explore these roles and will develop an integrated complex systems modelling, simulation and visualisation framework. This will be used on an exemplar application for lineage commitment in haematopoiesis and for exploring and validating genetic regulatory models in general.