The development of chemohypethermia using magnetoliposomes in magnetic field

在之前的研究中，我们研究了磁铁矿脂质体的电磁加热在癌症治疗中的温和消融作用。本研究的主要目的是确定是否可以通过磁铁将含有磁铁矿的脂质体吸引到肿瘤上来增强磁铁矿脂质体的治疗效果。用模拟人食道癌的TE-8细胞对裸鼠进行诱导加热处理。为探讨该方法对裸鼠肿瘤生长的影响，将裸鼠分为3组：加热组(磁铁)、加热组(无磁铁)和对照组。加热组(磁铁)用磁铁吸引荷瘤小鼠，荷瘤小鼠注射磁铁后置于交变磁场(AMF)下10min，而加热组(不加磁铁)在无磁铁的情况下注射磁铁脂质体，给予AMF治疗。肿瘤体积在对照组和其他组之间有显著差异。此外，加热组(磁铁)治疗3天后，肿瘤内可清晰地检测到磁铁矿脂质体。因此，这种新的消融方法可能是一种可行的癌症治疗技术。

In a previous study, we investigated electromagnetic heating with magnetite-loaded liposomes for the purpose of mild ablation in cancer treatment. The principal aim of this study was to determine whether the therapeutic efficacy of magnetite-loaded liposomes could be enhanced by attracting our liposomes containing magnetite to the tumor with magnet. Nude mice with TE-8 cells mimicking human esophageal cancer were treated by induction heating. To investigate the influence of this method on tumor growth, nude mice were assigned to 3 experimental groups: heating group (magnet), heating group (no magnet), and control group. In the heating group (magnet), magnetite-loaded liposomes were attracted to the tumor with a magnet and tumor-bearing mice placed for 10 min under an alternating magnetic field (AMF) after magnetite-loaded liposomes injection, while in the heating group (no magnet), magnetite-loaded liposomes were injected into each animal in absence of magnet and AMF treatment was administered. Tumor volume was significantly different between the control group and the other groups. Furthermore, the magnetite-loaded liposomes could be detected clearly in the tumor 3 days after treatment in heating groups (magnet). Thus, this new ablation method may be a feasible technique for cancer therapy.