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Investigating the mechanism of diabetes associated hearing impairment by aging.

Investigating the mechanism of diabetes associated hearing impairment by aging.
研究衰老引起的糖尿病相关听力损伤的机制。
批准号:
23791896
负责人:
FUJITA Takeshi
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

项目摘要

项目成果

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中文摘要
翻译
我们的目的是利用糖尿病小鼠研究1型糖尿病患者中糖尿病相关听力障碍的病理生理学。糖尿病组和对照组之间ABR阈值漂移的时间变化没有显著差异。然而,糖尿病组耳蜗蜗壳内的血管壁明显厚于对照组。此外,糖尿病小鼠从噪音引起的损伤中恢复明显受损。我们的数据表明,糖尿病耳蜗比对照组更容易受到噪音的影响。
英文摘要
We aimed to investigate the pathophysiology of diabetes- associated hearing impairment in type1 diabetes using mice with diabetes. Chronologic changes in the ABR threshold shift were not significantly different between the diabetic and control groups. However, vessel walls in the modiolus of the cochleae were significantly thicker inthe diabetic group than the control group. Additionally, recovery from noise-induced injury was significantly impaired in diabetic mice. Our data suggest that diabetic cochleae are more susceptible than controls to loud noise exposure.
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会议论文
Ken-ichi Nibu, Hearing impairments and cochlear changes in type1 diabetes model mice and diet-induced obesity mice
Ken-ichi Nibu,1 型糖尿病模型小鼠和饮食诱导肥胖小鼠的听力障碍和耳蜗变化
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Takeshi Fujita, Daisuke Yamashita, Sayaka Katsunuma, Shingo Hasegawa, Hitoshi Tanimoto]
通讯作者: Hitoshi Tanimoto
Hearing impairments and cochlear changes in Type1 diabetes model mice and diet-induced obesity mice
1型糖尿病模型小鼠和饮食诱导肥胖小鼠的听力障碍和耳蜗变化
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Fujita T, Yamashita D, Katsunuma S, Tanimoto H, Hasegawa S, Nibu KI.]
通讯作者: Nibu KI.
Hearing Function and Cochlear Morphology in Diabetes Mellitus Mice Model
糖尿病小鼠模型的听力功能和耳蜗形态
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Takeshi Fujita, Daisuke Yamashita, Sayaka Katsunuma, Shingo Hasegawa, Ken-ichi Nibu]
通讯作者: Ken-ichi Nibu
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [藤田岳, 山下大介, 丹生健一]
通讯作者: 丹生健一
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