A development of the way of bone transplantation using adipose derived stem cells

我们计划研究脂肪源性干细胞（ADSC）在供体能力方面是否能超过骨髓源性干细胞（BMSC）。在支架内的骨诱导培养基中进行诱导，并分别移植到兔下颌骨骨缺损中。4周后，我们采集组织，两组缺损的纤维化程度均低于对照组，但我们没有发现统计学上的显著差异。此外，ADSC和MSC都没有比对照组提供更多的骨重塑。这导致我们的研究，我们应该考虑在体外骨诱导的术语和事实转移组阻止缺陷纤维化意味着这种方法可能是一个有效的步骤，以防止骨破坏手术后的婴儿中面异常的临床病例骨退化。

We planned to examine whether adipose derived stem cells (ADSC) could surpass bone marrow derived stem cells (BMSC) for donor ability. Both of them were inducted in osteoinduction medium within scaffolds, and transferred into bone defect respectively that we made on rabbits' mandible. After 4weeks, we harvested the tissues, both of defects showed less fibrosis compared with control group, but we didn't detect significant differences between them statistically. Moreover neither of ADSC nor MSC provided more bone remodeling than controls. That lead us to the investigation that we should consider the term for osteo-induction in vitro and the fact transfer groups prevented defect fibrosis means this methods could be an effective step to prevent bone regression in clinical cases after osteodistruction surgery of infants suffering midface anomary.