The recovery mechanism and cell injury from orthodontic treatment with promoter of transplanted bone marrow-derived cell migration into periodontal tissues

在本研究中，我们旨在阐明正畸机械应力对牙周组织恢复和细胞毒性的分子调控机制，并阐明控制方法的发展，骨髓源性细胞的功能和动力学的全部细节。通过对小鼠进行骨髓源性细胞移植，阐明了骨髓源性细胞在周围骨组织中的参与作用，研究了细胞损伤对牙周韧带成纤维细胞特别是牙周韧带组织的影响，使其承载了小鼠磨牙正畸的学术能力。骨髓干细胞被证明可以移植到一个生长旺盛的部位，主要是在牙周组织中重塑，实验表明这种现象与神经系统的致密和细胞有关。

In this study, we aimed that the elucidation of the molecular regulation mechanism of recovery and cytotoxicity of periodontal tissue by orthodontic mechanical stress, and to clarify the development of the control method, the full particulars of the function and dynamics of bone marrow-derived cell.Using the mouse that performed the bone marrow-derived cell transplantation, and were elucidated the involvement of bone marrow-derived cell in the surrounding bone and tissue study of cell injury to receive the periodontal ligament fibroblasts in particular periodontal ligament tissue loaded with orthodontic academic ability in mouse molars. Bone marrow stem cells were shown to engraft in a thriving site remodeling mostly in periodontal tissue showed experimentally that this phenomenon is associated with the dense and cells of the nervous system.