Base metal "Iron"-catalyzed or mediated Preparation of Polyfunctionalized Compounds

本研究代表发展了利用铁催化剂与官能化碳-碳多重键的相互作用合成多官能化化合物的各种方法。 具体而言，开展了以下项目。1)铁催化选择性加成在格氏试剂官能化双烯上的应用。 2)铁催化的格氏试剂对磺酰基二烯或官能化烯炔的选择性加成。 3)铁催化的选择性取代在官能化二烯单环氧格氏试剂中的应用。 4)功能化二烯单环氧化合物在铁催化下的还原偶联反应-环丙烷的立体选择性合成。5)铁催化苄基醚和叔丁基过氧化氢选择性合成过氧缩醛。6)铁催化下硝基化合物与格氏试剂还原偶联制备胺。

This research representative developed various synthetic methodologies of polifunctionalized compounds by using interaction of iron catalyst and functionalized carbon-carbon multiple bonds. Specifically, the following items were carried out. 1) Application of iron-catalyzed selective addition to functionalized dienes of Grignard reagents. 2) Iron-catalyzed selective addition to sulfonyl dienes or functionalized enynes of Grignard reagents. 3) Application of iron-catalyzed selective substitution to functionalized diene monoepoxides of Grignard reagents. 4) Reductive homocoupling reaction of functionalized diene monoepoxides with iron catalyst-stereoselective synthesis of cyclopropanes. 5) Iron-catalyzed selective synthesis of peroxyacetals from benzyl ethers and tert-butyl hydroperoxide. 6) Iron-catalyzed preparation of amines from nitro compounds and Grignard reagents via reductive coupling reaction.