Development of near-IR responsive triple-targeting anti-cancer drug using efficient silyl-photosensitizer

为了开发近红外响应型抗癌药物，我们开发了由纳米药物载体、烯烃单元、光敏剂和高效的近红外响应型光敏剂组成的近红外响应性药物输送系统，估算了单线态氧对烯烃单元的解离效率，并讨论了将光敏剂从纳米载体上释放的可能性。我们还通过调节光吸收效率来改进光敏剂。

To develop the near-IR responsive anticancer drug, we have developed the near-IR responsive drug delivery system, which consists with nanosized drug carrier, olefin unit, and photosensitizer, and efficient near-IR responsive photosensitizer.We have estimated the dissociation efficiency of olefin unit by singlet oxygen and have discussed the possibility to release the photosensitizer from the nanosized carrier. We have also improve the photosensitizer by tuning light absorption efficiency.