Creation of novel silyl photosensitizer absorbed on nanoparticle for photodynamic therapy

综述了用于光动力治疗的光敏剂的研究进展。新型硅基光敏剂对单线态氧的敏化效率和细胞摄取效率均高于原硅基光敏剂。硅基化还提高了对肿瘤的选择性蓄积效率。硅烷化显著增强了荷瘤小鼠的光动力活性。为了提高纳米二氧化硅对肿瘤的选择性蓄积效率，将硅基光敏剂与二氧化硅纳米粒子进行了杂交。结果表明，杂化材料对有机溶剂中的单线态氧具有较高的敏化效率。

Developments of photosensitizer for photodynamic therapy were carried out. New silyl-photosensitizer shows higher sensitization efficiency of singlet oxygen and higher cellular uptake efficiency than previous one. The silylation also improved the selectively accumulating efficiency to tumor. Photodynamic activity for tumor-bearing mice was significantly enhanced by the silylation. Hybridization of a silyl-photosensitizer with silica nanoparticle was carried out to improve the selectively accumulating efficiency to tumor. It was confirmed that the hybrid material shows high sensitization efficiency of singlet oxygen in organic solvent.