Molecular pharmacological analyses of CRTH2, the type II PGD2 receptor, as a molecule regulating emotional function

虽然越来越多的证据表明前列腺素受体CRTH2在外周炎症中具有刺激作用，但对其脑功能了解甚少。本研究揭示了大脑CRTH2在小鼠疾病行为模型中的情绪障碍中的特异性参与，以及其在实验动物和人类受试者的认知调节中的可能作用。本研究还开发了CRTH2等的敲除系统，这将有助于对中枢神经系统中CRTH2的进一步分子分析。

Although accumulating evidences established stimulatory roles of prostanoid receptor CRTH2 in peripheral inflammation, its brain function is poorly understood. This study has revealed the specific involvement of brain CRTH2 in the emotional impairment in mice sickness behavior models, and its possible roles in the regulation of cognition both in experimental animals and human subjects. This study has also developed a knockdown system of CRTH2 etc., which will contribute to further molecular analysis of CRTH2 in the central nervous system.