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In vivo patch-clamp recording analysis of a pruritogen-induced itching on synaptic transmission in spinal dorsal horn

In vivo patch-clamp recording analysis of a pruritogen-induced itching on synaptic transmission in spinal dorsal horn
瘙痒剂引起的瘙痒对脊髓背角突触传递的体内膜片钳记录分析
批准号:
23790652
负责人:
UTA Daisuke
金额:
$2.83万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
翻译
瘙痒在脊髓背角的传递机制尚不清楚。本研究用全细胞膜片钳记录技术对啮齿动物脊髓背角神经元的瘙痒突触反应进行了分析。目前的主要发现是脊髓背角神经元亚群负责皮肤瘙痒的5-羟色胺刺激。
英文摘要
The mechanism for the itch transmission in the spinal dorsal horn remains unclear. The present study was designed to analyze pruritic synaptic responses evoked in spinal dorsal horn neurons of rodents by using an in vivo whole-cell patch-clamp recording technique. The present main finding is that subpopulation of spinal dorsal horn neurons are responsible for pruritic cutaneous serotonin stimulation.
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会议论文
In vivo patch-clamp analysis of pruriceptive and nociceptive synaptic transmission in the adult rat spinal dorsal horn
成年大鼠脊髓背角瘙痒和伤害性突触传递的体内膜片钳分析
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Uta D, Gotoh Y, Andoh T, Kuraishi Y, Imoto K, Furue H]
通讯作者: Furue H
DOI: 10.1186/1744-8069-7-101
发表时间: 2011-12-22
期刊: Molecular pain
影响因子: 3.3
作者: [Lu J, Katano T, Uta D, Furue H, Ito S]
通讯作者: Ito S
Excitatory effect of a pruritogen serotonin on synaptic transmission in adult rat spinal dorsal horn neurons in vivo
瘙痒原血清素对体内成年大鼠脊髓背角神经元突触传递的兴奋作用
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Uta D, Gotoh Y, Andoh T, Kuraishi Y, Imoto K and Furue H]
通讯作者: Imoto K and Furue H
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Shirakawa, H., Kusano, A., Miyake, T., Konno, M., Nakagawa, T., Kaneko, S., 歌 大介]
通讯作者: 歌 大介
共 43 条
    In vivo patch-clamp analysis of itch transmission in central nerve system
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