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Large-scale screening system of low molecular compounds forrealization of regenerative medicine for liver diseases

Large-scale screening system of low molecular compounds forrealization of regenerative medicine for liver diseases
低分子化合物大规模筛选系统,实现肝病再生医学
批准号:
23659650
负责人:
SHIOTA Goshi
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
翻译
为了筛选刺激人骨髓间充质干细胞向肝脏分化的小分子化合物,我们建立了一种基于细胞的筛选系统,该系统利用具有TCF基序的#7-1-2细胞,以剂量依赖的方式具有高荧光素酶活性,对Wnt/β-catenin信号持续稳定地反应。
英文摘要
In order to pick up low molecular compounds which stimulate hepatic differentiate of human mesenchymal stem cells, we have developed a cell-based screening system using the #7-1-2 cells, which have TCF motif and have high luciferase activity in a dose-dependent manner, constantly and stably respond to Wnt/beta-catenin signals.
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会议论文
Enhancing effect of retinoids on anti-cancerous drugs by regulating intracellular molecules
  • 批准号:
    25670368
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额:
    $2.33万
  • 财政年份:
    2013
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  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
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  • 财政年份:
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Development of expanding and differentiation-promoting system ex vivo for liver regeneration
Development of method of transdifferentiation of human umbilical cord blood cells to hepatocyte
  • 批准号:
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海外基金