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Challenging study of immunotherapy for osteosarcoma usingmicroparticles induced by photodynamic therapy

Challenging study of immunotherapy for osteosarcoma usingmicroparticles induced by photodynamic therapy
使用光动力疗法诱导的微粒进行骨肉瘤免疫治疗的挑战性研究
批准号:
23659730
负责人:
KUSUZAKI Katsuyuki
金额:
$2.33万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

项目摘要

项目成果

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中文摘要
翻译
本研究探讨了吖啶橙光动力诱导的微粒子免疫治疗对小鼠骨肉瘤肿瘤生长和肺转移的抑制作用。结果表明,这些微粒包括exQsomes并没有抑制肿瘤生长和肺转移,因为它们没有通过巨噬细胞激活免疫活性
英文摘要
In this study, we undertook to investigate inhibition effect oftumor growth and pulmonary metastasis on mouse osteosarcoma by immurlotherapy withmicroparticles induced by photodynamic therapy with acridine orange. Results showed thatthese microparticles including exQsomes did rlot inhibit tumor growth and pulmonarymetastasis, because they did not activate immunoactivity via macrophages
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会议论文
In Sarcoma Edited by Bulter EJ: Nova Science Publisher Inc.
《肉瘤》,Bulter EJ 编辑:Nova Science Publisher Inc.
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Kusuzaki K, Ashihara E, Hosogi S, Matsubara T, Satonaka H, Manamura T, Matsumine A, Murata H, Sudo A, Uchida A, Murata H, Baldini N, Fais S, Marunaka Y.]
通讯作者: Marunaka Y.
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Takao Matsubara, Katsuyuki Kusuzaki, Akihiko Matsumine, Akihiro Sudo]
通讯作者: Akihiro Sudo
Cancer microenvironment and new target cancer therapy
癌症微环境与癌症新靶点治疗
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Ito S, Nitta Y, Fukumitsu H, Soumiya H, Ikeno K, Nakamura T, Furukawa S., Kusuzaki K]
通讯作者: Kusuzaki K
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Soumiya H, Fukumitsu H, Furukawa S, 田中太晶, 楠崎克之]
通讯作者: 楠崎克之
共 30 条
    Development of rapid and simultaneous diagnosis and therapy for musculoskeletal sarcomas using acridine orange excited by high-power flash light
    • 批准号:
      19390390
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.82万
    • 财政年份:
      2007
    • 负责人:
      KUSUZAKI Katsuyuki
    • 依托单位:
    Development of photodynamic and radiodynamic therapy with acridine orange for new limb salvage surgery in musculoskeletal sarcomas
    • 批准号:
      14207058
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $16.06万
    • 财政年份:
      2002
    • 负责人:
      KUSUZAKI Katsuyuki
    • 依托单位:
    Development of a new surgical strategy in tumor resection for malignant bone and soft tissue tumors with cytocidal effect of acridine orange excited by various dynamic energy-wave.
    • 批准号:
      12470312
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $6.72万
    • 财政年份:
      2000
    • 负责人:
      KUSUZAKI Katsuyuki
    • 依托单位:
    Basic research on cell-biological feature of multidrug resistant osteosarcoma and overcoming of resistance
    • 批准号:
      07457340
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $4.8万
    • 财政年份:
      1995
    • 负责人:
      KUSUZAKI Katsuyuki
    • 依托单位:
    海外基金