Identification of target molecules against anti MuSK IgG in Myasthenia Gravis

重症肌无力(MG)是由神经肌肉连接蛋白自身抗体引起的自身免疫性疾病。反马斯克MG占MG的15%，但还不清楚。麝香是NMJ的膜转移蛋白，胞外区含有IG1、IG2、IG3、IG4和C6盒。在这项研究中，来自五个人的抗麝香抗体同时抑制了麝香-ColQ和穆斯克-LRP4的相互作用。此外，麝香抗体识别免疫球蛋白1和免疫球蛋白4，LRP4也结合免疫球蛋白1和免疫球蛋白4。

Myasthenia Gravis (MG) is antoimmuno disease caused by an antoantibody to protein consisting of neuromuscular junction. Anti MuSK MG account for fifteen percent of MG ,but it is unclear well. MuSK is membrane transfer protein of NMJ, and has Ig1, Ig2, Ig3, Ig4 and C6 box in extracellar region. In this study, it was demonstrated that anti-MuSK antibody from five persons inhibit both MuSK-ColQ and MuSK-LRP4 interaction. Moreover, MuSK antibody recognizes Ig1 and Ig4, and LRP4 also binds Ig1 and Ig4.