Functional significance of microtubuledynamics controlled counteractively by cAMP and cGMP

在发育过程中，神经元会延伸轴突，与靶细胞建立联系。在延长的轴突顶端的生长锥感知细胞外环境中的指导线索，因此在建立适当的连接方面起着中心作用。阐明细胞内调节生长锥引导的事件对于理解神经元回路组装的基础是至关重要的。在这个项目中，我证明了环核苷酸通过调节生长锥体中微管依赖的囊泡运输来调节轴突引导。

During development, neurons extend axons to make connections with the targets. The growth cone at the tip of the elongating axon senses guidance cues in the extracellular environment and thus plays a central role in establishing the proper connections. Elucidating intracellular events mediating growth cone steering is essential for understanding the basis of neuronal circuit assembly. In this project, I showed that cyclic nucleotides mediate axon guidance by regulating microtubule-dependent vesicle transport in the growth cones.