Search for antitumor compounds from symbiotic or parasitic microbes in aquatic multicellular organisms

在这项研究中，研究人员旨在有效地寻找新的抗肿瘤药物。从水生生物中分离培养出约1000株微生物。从代谢产物中分离出抗肿瘤细胞的细胞毒性化合物。其中13个化合物为已知化合物，8个化合物为新化合物。研究人员建立了使用多个培养细胞系的细胞毒性评价和比对系统。利用该体系，发现了一种新的化合物香菇海藻糖，并推出了蛋白磷酸酶2A特异性抑制剂红曲霉毒素A作为分子探针。

In this study, the researcher aimed for efficient searching of new antitumor agents. About 1000 strains of microbes were isolated from aquatic organisms and cultured. Cytotoxic compounds against cancer cells were isolated from the metabolites. While 13 known compounds were identified, 8 compounds were estimated as novel compounds. The researcher established the evaluation and comparison system of cytotoxicity employing multiple culture cell lines. Harnessing the system, a novel compound lentztrehalose was discovered and a protein phosphatase 2A specific inhibitor rubratoxin A was launched as a molecular probe.