Preparation of functional hydrogels composed of filamentous viruses

为了制备由丝状病毒组成的功能性水凝胶，利用了基因工程改造的M13噬菌体（M13）和表面修饰的金纳米颗粒（GNP）。在合适的浓度条件下混合组分后，混合溶液自组装成水凝胶。水凝胶中的纳米粒子和纳米颗粒分别形成溶致液晶和有序的分形网络结构。此外，发现病毒水凝胶的机械强度依赖于病毒载体和GNP之间的特定分子相互作用。此外，水凝胶显示出多种功能，如自修复能力和对大肠杆菌存在的响应性。

For the preparation of functional hydrogels composed of filamentous viruses, genetically engineered M13 bacteriophages (phages) and surface-modified gold nanoparticles (GNPs) were utilized. After mixing of the components under the suitable concentration condition, the mixed solutions were self-assembled into hydrogels. The phages and the GNPs in the hydrogels formed lyotropic liquid crystals and well-ordered fractal like network structures, respectively. Furthermore, it was found that mechanical strengths of the viral hydrogels were dependent on the specific molecular interactions between the phages and the GNPs. Furthermore, the hydrogels showed various functions such as self-repairing capabilities and responsiveness for existence of Escherichia coli.