Tail-anchored membrane proteins: prediction, targeting, assembly and function.
Tail-anchored membrane proteins: prediction, targeting, assembly and function.
批准号:
DP0208783
负责人:
Prof Trevor Lithgow
金额:
$22.21万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2002
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2002-01-01 至 2006-12-31
中文摘要
利用计算机对基因组序列数据的搜索,我们现在有了一个完整的酿酒酵母尾部锚定膜蛋白的列表。这些蛋白质包括一些基本蛋白质,如SNARES和TOM蛋白质,它们负责在包括人类在内的所有生物体中建立细胞膜。在搜索中发现的额外蛋白质序列中,8个代表已知功能的蛋白质,19个是新的。我们建议研究这19个新蛋白的亚细胞位置,并解决它们是如何被靶向和插入膜的。我们还将研究新发现的蛋白质的功能。
英文摘要
Using computer-based searches of genome sequence data, we now have a complete list of tail-anchored membrane proteins in the yeast Saccharomyces cerevisiae. These include a number of essential proteins, such as SNAREs and TOM proteins responsible for building cellular membranes in all organisms, including man. Of the additional protein sequences discovered in the search, 8 represent proteins of known function while 19 are novel. We propose to study the subcellular location of these 19 novel proteins, and solve how they are targeted to and inserted in membranes. We will also investigate the function of the newly-discovered proteins.
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海外基金