Preparation of chiral metal-free Lewis acids and their application in asymmetric catalysis

该提案涉及几乎未开发的无金属路易斯酸合成领域的发展，从一开始就集中在不对称催化的例子上。无金属工艺对未来至关重要，因为金属在合成中的应用是诸如高价格、毒性、污染、废物处理和产品污染等巨大问题的来源。所需的路易斯酸，如共振稳定碳阳离子，可以很容易地在几个步骤和大规模制备廉价的起始材料，结构和电子特征可以很容易地修改。手性催化剂将广泛应用于合成重要的不对称反应以制备对映不纯化合物。后者具有非凡的意义，特别是当靶标被用作药物时。通常，当一种对映体显示出预期的效果时，另一种对映体却没有。在更糟糕的情况下，相反的对映体可能有毒或致畸。对映不纯化合物在农用化学品、香精、香料和许多其他产品中也很重要。

The proposal deals with the development of the nearly unexplored field of metal-free Lewis acids in synthesis, focusing already from the very beginning on asymmetric catalytic examples. Metal-free processes are of paramount importance for the future, since the application of metals in synthesis is a source of enormous problems such as high price, toxicity, pollution, waste treatment and product contamination. The desired Lewis acids, e. g. resonance stabilized carbocations, can be readily prepared in only a few steps and on a large scale from cheap starting materials and structural and electronic features can be easily modified. The chiral catalysts will be applied to a broad range of synthetic important asymmetric reactions to prepare enantiopure compounds. The latter are of extraordinary significance, especially if the target is used as a drug. Often, while one enantiomer shows the desired effect, the other does not. In worse cases, the opposite enantiomer can be toxic or teratogenic. Enantiopure compounds are also of importance in agrochemicals, flavors, fragrances and many other products.