Effect of inflammatory cytokine for bone recovery
Effect of inflammatory cytokine for bone recovery
批准号:
24792171
负责人:
YAMAZAKI Masato
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
分别于骨折后0、1、2、7天取骨髓细胞,用聚合酶链式反应(PCR)进行RNA分析。在骨折后第1天,促炎细胞因子--TNFa、IL-6和IL-1b的表达增加。尤其是IL-6表达上调。DA2、RANKL(核因子-kB受体激活剂)、ALP(碱性磷酸酶)和Osterix表达上调。之后,我们将控制促炎细胞因子的表达,并分析影响骨愈合的主要因素。
英文摘要
We fractured mouce thighbone.Bone marrow cell corected for 0,1,2,7days after fracture.We analyzed RNA by PCR. The expression of proinflammatory cytokines what is TNFa,IL-6 and IL1b was increased in the first day after fracture. Especially, IL-6 expression was upregulation. Day2, RANKL(receptor activator of nuclear factor-kB ligand), ALP(alkaline phosphatase)and osterix was upregulated. After this, we will control proinflammatory cytokines expression, and analyze most influence factor for bone healing.
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会议论文
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依托单位:
国内基金
海外基金
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项目类别:面上项目
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依托单位: