The role of Keap1-Nrf2 system in obesity-induced pancreatic beta-cell dysfunctions

Keap1-Nrf2系统有助于抵抗包括氧化应激在内的环境应激。糖尿病是一种具有严重并发症的代谢性疾病，保护胰腺β细胞功能障碍对抑制糖尿病的发生和发展至关重要。激活Keap1-Nrf2系统强烈抑制肥胖诱导的糖尿病模型小鼠胰腺β细胞功能障碍。Nrf2激活诱导肥胖诱导糖尿病模型小鼠离体胰岛抗氧化基因这些结果表明，Keap1-Nrf2系统可能是保护胰腺β细胞免受肥胖诱导的功能障碍的靶标。

The Keap1-Nrf2 system contributes to protect against environmental stress including oxidative stress. Diabetes mellitus is a metabolic disorder with severe complications, and the protection from pancreatic beta-cell dysfunction is important for the suppression of onset and progression of diabetes mellitus. Activation Keap1-Nrf2 system strongly suppressed pancreatic beta-cell dysfunction in obesity-induced diabetic model mice. Nrf2 activation induced antioxidant genes in isolated islets from obesity-induced diabetic model mice. These results indicate that the Keap1-Nrf2 system probably is a target for the protection of pancreatic beta-cells against obesity-induced dysfunctions.