Gen-Umwelt-Interaktion beim Aufmerksamkeitsdefizit-/Hyperaktivitätssyndrom (ADHS)

注意力缺陷多动障碍（ADHD）是一种以注意力不集中、多动和冲动为特征的复杂的儿童综合征。越来越多的证据表明，遗传易感性和早期生活（产前/产后）的心理社会环境之间的相互作用参与了ADHD的发病机制。研究将在由三个儿童精神病学临床单位（特里尔大学、洪堡/萨尔大学和维尔茨堡大学）进行的多中心合作研究框架内进行，并计划由特里尔大学组织的DFG研究小组重点关注压力受损的产前和产后发育。我们想建立一个DNA和数据收集从一个大样本的parentoffspring三人组和/或受影响的同胞对多动症进行遗传，心理和行为研究，并确定基因环境相互作用的作用在多动症。

Attention deficit and hyperactivity disorder (ADHD) ist a complex childhood syndrome characterized by inattention, hyperactivity, and impulsivity. A growing body of evidence points to the interplay between genetic vulnerability and psychosocial circumstances in early life (prenatal/postnatal) being involved in pathogenesis of ADHD. Research will take place within a framework of a multicenter collaboration study conducted by three clinical units of child psychiatry (Universities of Trier, Homburg/Saar, and Wuerzburg), and a planned DFG-Research Group organized by the University of Trier that fucuses on stress-impaired pre- and postnatal development. We would like to establish a DNA and data collection from a large sample of parentoffspring trios and/or affected sib pairs with ADHD to conduct genetic, psychosocial, and behavioral studies, and to define the role of gene-environment interactions in ADHD.