Development of stimulus-responsive cellulose nanocrystals based on terminal functionalization method and its biomedical application

采用T形、Y形和同心圆三种不同的设计方案，采用光刻技术在硅片上连续制备了纤维素纳米晶(CNCS)的微流控器件。通过数控加工所需的酸性溶液和纤维素悬浮液，对装置的效率进行了分析。在第二个项目中，我们利用植物来源和微生物来源，通过可持续和更绿色的路线开发了功能化纳米纤维素(NC)基复合材料，为其作为高性能复合材料的潜在应用奠定了基础。该项目的主要目的是利用不同类型的废木质素衍生物，如碱木质素(AL)和化学修饰阳离子木质素(Catlig)作为NC生物处理的前体。这项工作展示了一种独特的方法，利用木质素作为现场BC发酵的智能添加剂，同时作为微生物生长的促进剂和多功能复合材料的增强填料。在第三个项目中，我们在我们的研究中使用了Hinoki木材，并开发了一种新的方法来生产脱木素木材(DW)，同时保留了它们有趣的多尺度分层微结构。此外，对DW进行了战略性的化学修饰，以开发透明木材，该木材在不同行业的潜在应用已申请专利。

The microfluidic device was fabricated for continuous production of Cellulose Nanocrystals (CNCs) on silica wafers through lithography techniques with three different designs of T-shape, Y-shape, and concentric circles. The efficiency of the device was analyzed by passing the acid solutions and cellulose suspension require for CNC production. In second project, we developed functionalized nanocellulose (NC) based composites using plant-derived and microbial source through sustainable and greener routes for their potential application as high-performance composites. The main aim of the project is to utilize different types of such waste lignin derivatives such as alkali lignin (AL) and chemically modified cationic lignin (Catlig) as a precursor to NC bioprocessing. This work demonstrates a unique approach of utilizing lignin, as a smart additive to in situ BC fermentation in which it concurrently acts as a promoter to microbial growth as well as reinforcing filler for fabrication of multifunctional composites. In third project, we have used Hinoki wood in our research and have developed a novel approach for production of delignified wood (DW) with the retention of their interesting multi-scale hierarchical micro-architecture. Further, a strategic chemical modification of DW has been carried out to develop transparent wood, which finds potential applications in different sectors have been applied for patent.