Control and evolution of somite pattern formation during early development (C06)

脊椎动物的体细胞发生正在不同的动物中被研究，其理解已经达到了理论建模可以提供重要见解的水平。在这里，我们关注与体细胞发生时钟有关的基因的振荡表达模式的进化转变。这种转变似乎发生在斑马鱼和Medaka之间。我们将使用理论建模来研究控制体细胞发生的调控网络的表型变异性，并将进行实验来表征关键时钟元件的调控进化的影响。

Vertebrate somitogenesis is being studied in a diverse set of animals, and ist understanding has reached a level where theoretical modeling can provide important insights. Here, we focus on an evolutionary transition in the oscillatory Expression pattern of the genes involved in the 'somitogenesis clock*. Such a transition appears to have occurred between Zebrafish and Medaka. We will use theoretical modeling to study the phenotypic variability of the regulatory network controlling somitogenesis, and will perform experiments to characterize the effects of the regulatory evolution in key clock elements.