"Entwicklung und Klinische Implementierung neuer Verfahren zur Dosismessung in der Strahlentherapie mit Schwerionen"

欧洲第一家基于医院的离子束治疗设施（HIT）于2009年在海德堡大学开始运营。该设施提供了理想的可能性，为各种肿瘤疾病提供高度准确和有效的放射治疗。然而，仍然需要将施加到患者的剂量的确定的准确度提高到与利用高能光子束的常规放射治疗相似的水平。特别是，需要通过寻找更有效的检测器来改进程序，取代目前使用的空间分辨率有限的电离室。该项目的目的是找到一种探测器，它可以几乎连续地确定空间中的剂量分布，并满足安全和准确性的所有要求。因此，我们计划研究新的探测器，包括高空间分辨率和在线读出，特别是像素化的基于探测器的剂量学特性，并调查其适用于离子束剂量学。蒙特卡罗模拟技术允许直接计算探测器中的物理相互作用，将应用于了解探测器的响应。最后，新的探测器和剂量测定方案必须转移到离子束治疗设施的临床常规中，以有助于进一步改进离子束治疗。

The first European hospital based ion beam therapy facility (HIT) started its operation in 2009 at the University of Heidelberg. The facility offers ideal possibilities to deliver a highly accurate and effective radiotherapy for a variety of tumour diseases. There is, however, still a need to raise the accuracy of the determination of dose applied to the patient to a similar level as in conventional radiation therapy with high energy photon beams. In particular, there is a need to improve the procedures by finding more efficient detectors, replacing the currently used ionization chambers providing limited spatial resolution. The aim of this project is to find a detector which would allow to determine the dose distribution nearly continuously in space and which would accommodate all the demands of safety and accuracy. Therefore we plan to examine dosimetric properties of new detectors comprising high spatial resolution and online readout, in particular pixelized semiconductorbased detectors, and to investigate their suitability for ion beam dosimetry. The technique of Monte Carlo simulations, which allows a direct calculation of the physical interactions in the detector, will be applied in order to understand the response of the detectors. Finally, the new detectors and dosimetry protocols have to be transferred to the clinical routine at the ion beam therapy facility in order to contribute to further improvements of ion beam therapy.