Understanding working memory: from cells to brain stimulation

该项目旨在了解工作记忆的神经机制，这是人类的基本认知功能，使用一种新的框架，该框架结合了非侵入性脑刺激，神经成像，药理学和实验操作以及生物建模。预期成果包括对健康个体神经活动和工作记忆能力的细胞机制的批判性理解，以及如何使用脑刺激与这些机制进行非侵入性交互的详细知识。这将带来显著的好处，例如开发个性化优化的脑刺激方案，使定制的方法能够可靠地改变大脑功能和认知。

This project aims to understand the neural mechanisms of working memory, a fundamental cognitive function in humans, using a novel framework which combines non-invasive brain stimulation, neuroimaging, pharmacological and experimental manipulations, and biological modelling. Expected outcomes include a critical understanding of the cellular mechanisms underlying both neural activity and working memory ability in healthy individuals and a detailed knowledge of how to non-invasively interact with these mechanisms using brain stimulation. This will provide significant benefits such as the development of individually optimised brain stimulation protocols, enabling tailored approaches to reliably alter brain function and cognition.