Effect of Chinese medicated diets on serum level of insulin-like growth factor I related to the development of osteoporosis

目的骨质疏松是导致老年人卧床不起的主要危险因素之一。中医认为，肾功能与骨代谢有关。提示补肾中药食疗是预防骨质疏松症的有效途径之一。先前的研究表明，较高的胰岛素样生长因子I （IGF-I）水平与老年妇女较高的骨密度有关。因此，本研究的目的是对与肾功能相关的中药进行分类，并确定IGF-I与CMD的关系。方法(1)食疗中药分类：按食物种类、性质、口味、经道倾向对288种含中药食品进行分类。(2) 1998年共有277名年龄在50至69岁之间的妇女参加了骨密度检查。我们在1998年和1999年进行了饮食习惯、肾虚的健康检查，并采集了更多的血液样本。受试者被要求在1998年10月至1999年1月期间每天吃以下面包：阴虚者用大豆、芝麻和枸杞做面包，阳虚者用肉桂、核桃和枸杞做面包。我们检测了与对照组（非阴阳虚组）相比，吃面包前后血清IGF-I和骨钙素水平的变化率平均值。结果(1)食品性质中中性的比例最高（36.5%），口味中以甜食为主（69.8%）。归经型以胃为证（48.2%），脾为证（30.2%）。提示食疗中药可通过健脾益胃来促进健康。(2)阴虚组血清IGF-I和骨钙素水平明显高于对照组。阳虚组血清IGF-I和骨钙素水平略高于对照组。结论中药补肾祛虚中药可显著提高血清IGF-I水平。这一发现表明CMD可以改善骨矿化和骨质疏松症的发展。少

PurposeOsteoporosis is a major risk factor for bone fraction, which makes elderly people be bedridden. According to traditional Chinese medicine (TCM), kidney function is related to bone metabolism. This suggests that one of prevention of osteoporosis is to take Chinese medicated diets (CMD) reinforcing kidney function. Previous studies have indicated that higher insulin-like growth factor I (IGF-I) levels are associated with greater bone mineral density in old women. Therefore the aim of this study is to classify dietetic Chinese Drugs which are related to kidney function and to determine the association between IGF-I and CMD.Methods(1) Classification of dietetic Chinese drugs : A total of 288 foods including chinese drugs were classified by food type, nature, taste, channel tropism.(2) A total of 277 women aged 50 to 69 who had taken examination about bone mineral density were enrolled in 1998. We conducted health examination concerning dietary habits, kidney deficiency and collected … More blood sample in 1998 and 1999. Subjects were asked to take the following bread every day between Oct. in 1998 and Jan. in 1999 ; bread including soy bean, sesame and Chinese matrimony vine for Yin-deficiency group, bread including cinnamon, walnut and Chinese matrimony vine for Yang-deficiency. We examined mean values of change rates in serum levels of IGF-I and osteocalcin before and after taking bread compared with control group (non-Yin and Yang deficiency group).Results(1) The proportion of neutral showed the highest (36.5%) in nature of food, of taste, sweets is most dominant one (69.8%). In channel tropism, stomach showed (48.2%) and spleen indicated (30.2%). This result suggested that dietetic chinese drugs can promote health status through spleen and stomach.(2) Yin-deficiency group had significantly greater increase in serum levels of IGF-I and osteocalcin as compared with control group. Serum levels of IGF-I and osteocalcin in Yang-deficiency group were slightly higher than those in control group.ConclusionThe intake of CMD reinforcing kidney deficiency according to traditional Chinese medicine significantly increased serum level of IGF-I. This finding suggested that CMD improves bone mineralization and the development of osteoporosis. Less