Neuronal activities of lumbar dorsal horn cells in rats model of lumbar radiculopathy

为探讨周围神经卡压伤患者感觉减退、感觉异常等异常感觉，我们建立了动物神经卡压模型，观察了背角神经元反应的变化。实验在麻醉的雄性SD大鼠身上进行。记录腰背角宽动态范围(WDR)细胞(n=13)在神经压迫前、压迫时和松解后对皮肤刺激(刷子、压力、挤压)的反应。神经元的深度距脊髓背侧500~1200微米。用小血管夹夹闭坐骨神经造成神经卡压(夹紧力120g)。湿润贴在30 mm的时间内。到目前为止的结果表明，神经压迫后，对无害刺激(刷状刺激)的反应减弱，但对伤害性刺激(夹痛)的反应没有影响。蜂巢，嗯。结果表明，在背角WDR神经元中，对无害刺激(Aβ)的反应比对伤害性刺激(A/C)的反应更有可能因神经压迫而减弱。

To investigate abnormal sensation such as hypesthesia, paresthesia, etc. observed in natient with peripheral nerve compression injury, we produced animal nerve compression model and observed the reactions of dorsal horn neuronal responses. Experiments were done in anesthetized male Sprague-Dawlev rats. Responses of wide dynamic range (WDR) cells (n=13) in the lumbar dorsal horn to cutaneous stimuli (brush, pressure, pinch) were recorded before and during nerve compression and after releasing of the compression. Depths of the neurons were 500-1200 mu m from the dorsal surface of the spinal cord. Nerve compression was produced by sciatic nerve applied small vessel clamp (120g of pinch force). The damp was attached 30 mm of duration. The results obtained so far, indicate that after the nerve compression, responses to the innocuous stimuli (brush) were decreased but responses to the noxious stimuli (pinch) were not affected. hive mm. after detachment of the nerve clamp, 11 neurons demonstrated increased brush responses temporarily.Present results suggest that in dorsal horn WDR neurons, responses to innocuous stimuli (A BETA )were more likely to he decreas by the nerve compression than those to noxious stimuli (Adelta/C).