Virus Receptors and Cytokines

与Verma博士合作（Salk研究所，美国）O 'Brien博士（NCI，美国）Durandy博士（INSERM，法国）及其关于细胞激素的同事，SDF-1，是CXCR 4的天然配体，是T型艾滋病毒的携带者。为了确定我们发现的艾滋病事件集的已知分子机制被推迟，在那些携带SDF 1基因艾滋病延迟型多态性的人身上，血液SDF-1集中在每个个体携带每个基因型都被测量的人身上。因此，新的测量系统命名为SDF-1 TR-FIA是在与松本博士合作开发的（早稻田大学）CREST）和血样是O 'Brien博士收集的。衡量工作仍在进行中.....。在我们的SDF-1表达系统中，CXCR 4在CD 4中D1+ D1细胞在SDF-1中的存在，显示延迟的分子机制。我们正在筛选附加多态性网站与SDF 1基因艾滋病延迟类型多态性网站链接。

Collaboration was done with Dr.Verma (SALK Institute, U.S.A.), Dr.O'Brien (NCI, U.S.A.), Dr. Durandy (INSERM, France) and their colleagues on a cytokine, SDF-1, which is the natural ligand for CXCR4, the coreceptor for T tropic HIV virus.1. To understand molecular mechanism of our finding that AIDS onset is delayed in the persons who bear homozygous alleles of SDF1 gene AIDS delaying type polymorphysm, the blood SDF-1 concentration in each individuals bearing each genotype was measured. For that, new measuring system named SDF-1 TR-FIA was developed in collaboration with Dr.Matsumoto (Waseda Univ./CREST) and blood samples were collected by Dr.O'Brien. The measuring work is still on going.2. In our SDF-1 expression system in vivo, CXCR4 on CD4ィイD1+ィエD1 cells were down-modulated in the presence of excess amount of SDF-1, showing the molecular mechanism of the delay.3. We are screening additional polymorphic site linked with the SDF1 gene AIDS delaying type polymorphysm.