NEW OILY AGENTS FOR TARGETING CHEMOTHERAPY FOR HEPATOCELLULARCARCINOMA

本研究的目的是评价新的油性药物靶向化疗栓塞治疗肝细胞癌。将5种油制剂注射于54只接种VX2癌细胞的兔肝动脉内，评价其安全性、组织学分布及肿瘤部位残留量及CT图像。在这些制剂中，有三种是通过将非碘化罂粟籽油和一种较稠的油混合而成，然后调整其粘度，使其低于、等于或高于脂醇。第四种制剂是脂醇和黏度比脂醇单独高的增稠剂的混合物，第五种制剂是脂醇单独。结果：(1)血液学和组织学均未见肝实质损伤。(2)随着黏度的增加，残留在肿瘤部位的药物数量明显增加。动脉内注射后14天正常部位无任何药物出现，无论给予哪种制剂。(3)在动脉注射后的CT扫描中，非碘制剂组肿瘤细胞可见深度染色，而脂醇组因衰减过高而未被评价。综上所述，本研究开发的非碘化油性制剂和高粘性油性制剂在治疗肝脏肿瘤方面比脂醇更有效

Evaluation of new oily agents for targeting chemoembolization for hepatocellular carcinomais aim of this study. Five kinds of oil preparations were injected into the hepatic artery of 54 rabbits inoculated with VX2 carcinomacells in order to evaluate (1) the safty of these preparations, (2) their histological distribution and the amounts of agents remaining at tumor sites, and (3) CT images obtained. Of these preparations, three were made by mixing non-iodinated poppy seed oil and a thicker and then adjusted to have a viscosity lower than, equal to, or higher than of lipiodol. A fourth preparation was a mixture of lipiodol and a thickener with higher viscosity than lipiodolalone, and the fifth preparation was lipiodolalone.Results below was obtained : (1) No injury to the hepatic parenchyma was obtained hematologicallyor historogically. (2) With increase in the viscosity, a significant larger amount of agent remained at the tumor site. No agent was present at normal sites 14 days after intraarterial injection, regardless of which preparation was given. (3) On CT scans following intra-arterial injection, tumor cell was visibly deeply stained in the non-iodinated preparation groups, while the lipiodol groups were not evaluate because of excessively high attenuation.In conclusion, The non-iodinated oily preparations and highly viscous oily preparations developed in the present study were more useful than lipiodol for treatment of hepatic tumors