MEDIC - MicroED Imaging Center - Admin Core

行政管理 摘要 行政核心(AC)将为拟议的多名调查员提供一个组织框架 项目，加州大学洛杉矶分校的医疗-微ED成像中心。咨询委员会将由两名私人助理Tamir Gonen博士领导 还有帕维尔·彭泽克。医疗中心的联合主管将确保资源的有效运作 不受私人助理的其他职责的干扰。该核心的活动将包括同步 所有小组的研究和技术开发，维持与各小组之间的交流 推动生物项目，解决预算问题，组织内部每月会议 咨询委员会，一次外部咨询会议的年度会议，最多两次培训和传播 每年举办一次研讨会。它还将负责编写年度进度报告，并将 并更新资源共享设施。该中心将受益于戈南博士在以下领域的丰富经验 管理低温EM资源和多用户设施项目。戈南博士建立并指导了几个低温电子显微镜 过去15年在美国各地的设施，包括Janelia最多产的低温EM用户设施 HHMI的研究园区，这是世界上第一个类似同步加速器的低温EM设施。彭泽克博士已经 20年来成功参与NIH支持的研究，包括参与多PI计划项目并加入PI 资助金。此外，彭泽克博士担任犹他州结构生物学成像中心主任长达12年之久， 支持德克萨斯大学医学中心结构生物学研究的多用户设施，包括核磁共振、X射线 结晶学和低温EM，并在独立的预算下运营。在他的领导下，工厂不断发展壮大， 最终在2017年成功收购了UT资助的Krios TEMs。自2017年以来，彭泽克博士担任 德克萨斯大学中心的联席主任。Gonen博士和Penczek博士将共同组建一个内部咨询委员会 由技术研究和开发项目(TRD)的精英成员组成，并选择关键 人事部。该委员会将建立并确保医务人员，通道的最佳操作程序 确定合格项目的程序和标准。它还将负责确定和 技术传播讲习班的形式，如有必要，在研究与开发项目之间重新分配资金。 最重要的是设立外部咨询委员会。本委员会的作用将是 就项目的总体科学方向提供建议，就传播努力和社区提供建议 参与，有助于保持其专注，并保持对医务人员最初使命的忠诚和忠诚。这个 行政核心将每年组织一次为期一天的外部咨询委员会及其成员会议 预计将编写一份报告，与项目的所有个人助理和关键人员以及 国家卫生研究院。

ADMINISTRATION AND MANAGEMENT SUMMARY The Administrative Core (AC) will provide an organizational framework for the proposed multi-investigator project, the MEDIC – MicroED Imaging Center at UCLA. The AC will be led by the two PIs, Drs. Tamir Gonen and Pawel Penczek. The joint directorship of the MEDIC center will ensure efficient functioning of the Resource uninterrupted by other responsibilities of the PIs. The activities of this Core will include synchronization of the research and technology development of all groups, the maintenance of communications with and between Driving Biological Projects, the resolution of budgetary issues, organization of monthly meetings for an Internal Advisory Committee, a yearly meeting of an External Advisory Meeting, and up to two training and dissemination workshops per year. It will also be responsible for the preparation of the yearly Progress Report and will maintain and update the Resource Sharing facility. The center will benefit from Dr. Gonen having extensive experience in managing cryoEM resources and multi-user facility projects. Dr. Gonen established and directed several cryoEM facilities around the USA in the last 15 years, including the most prolific cryoEM user facility at the Janelia Research Campus of HHMI which was the first synchrotron-like facility for cryoEM in the world. Dr. Penczek has 20 years of successful NIH-supported research including participation in multi-PI program project and joined PI grants. In addition, for 12 years Dr. Penczek served as a Director of the UTH Structural Biology Imaging Center, a multi-user facility supporting structural biology research at UT Medical Center, including NMR, X-ray crystallography, and cryo-EM and operating under an independent budget. Under his leadership the facility grew, culminating in the successful acquisition of a UT-funded Krios TEM in 2017. Since 2017 Dr. Penczek serves as a co-director of the UT Center. Together, Drs. Gonen and Penczek will formulate an Internal Advisory Committee comprised of elite members of the Technology Research and Development projects (TRDs) and select key personnel. This committee will establish and ensure optimal operating procedures for MEDIC, access procedures and criteria for determining eligible projects. It will be also responsible for determination and the format of technology dissemination workshops and, if necessary, for reallocation of funds between TRD projects. Of utmost importance is the establishment of the External Advisory Committee. The role of this Committee will be to advise on the overall scientific direction of the project, advise on dissemination efforts and community engagement, help to maintain its focus and to stay devoted and faithful to the original mission of MEDIC. The Administrative Core will organize a yearly one-day meeting of the External Advisory Committee and its members will be expected to prepare a report that will be shared with all PIs and key personnel of the Project and with the NIH.