Administrative Core

行政核心 摘要 行政核心的目的是作为本计划项目“基因”的汇聚点 人类横膈疝的突变和拯救”，核心的主要使命是监督其 准确性，完整性和生产力，并阐明整体计划的短期和长期愿景。 行政核心将提供基础设施，以促进 研究人员，以达到法定人数对项目的决定，以维持人类受试者的研究和动物 研究协议，并监督与这一努力有关的预算和财务。核心还将提供一个 数据和安全监测、科学质量、道德诚信和冲突解决的监督机制 通过召集内部和外部咨询委员会。行政核心将协调基因组 平台服务和样品制备（例如，测序）与招募和表型核心和项目I 以及协助将这些平台输出的基因组数据转移到生物信息学核心， 到本地存档存储。核心的总体目标是培养沟通和创新， 简化数据、资源、供应和结果在 项目和核心作为一种最大限度地提高时间和整合成本的方式。

ADMINISTRATIVE CORE ABSTRACT The purpose of the Administrative Core is to serve as the convergent point for this Program Project “Gene Mutation and Rescue in Human Diaphragmatic Hernia”, with the prime mission of the Core to oversee its accuracy, integrity, and productivity, and to articulate the short and long term vision of the Overall Program. The Administrative Core will provide the infrastructure to facilitate frequent communication between the investigators, to achieve quorum on project decisions, to maintain human subjects research and animal research protocols, and to oversee budgets and finance related to this effort. The Core will also provide a mechanism for oversight of data and safety monitoring, scientific quality, ethical integrity, and conflict resolution by assembling both internal and external advisory boards. The Administrative Core will coordinate genomic platform services and sample prep (e.g., sequencing) with the Recruitment and Phenotyping Core and Project I as well as assisting in the transfer of genomic data output from these platforms to the Bioinformatics Core and to local archived storage. The Core’s overall objective is to cultivate communication and innovation and assist to streamline the overall Program workflow of data, resources, supplies, and results between and among the Projects and Cores as a way to maximize time and consolidate costs.