Probing the role of dynamics in protein modulation of GPCR phenotype

生命依赖于将外部刺激转化为适当的生物反应的基本能力。这种刺激是由细胞表面蛋白(受体)传递的，它将这种刺激转化为细胞内信号。细胞表面受体中最大的一类是G蛋白偶联受体(GPCR)家族。尽管在gpr结构测定方面取得了进展，但关于gpr功能和信号转导的结构基础的许多问题仍然没有得到回答。该项目的主要成果是提供了对GPCR配体识别和激活动力学的机械性见解，以促进我们对GPCR信号转导的理解，GPCR信号转导是所有生物的基本生物学过程。

Life relies upon the fundamental ability to convert external stimuli into an appropriate biological response. Such stimuli are transmitted by cell surface proteins (receptors), which convert this stimulus into an intracellular signal. The largest group of cell surface receptors is the G protein-coupled receptor (GPCR) family. Despite advances in GPCR structure determination, many questions regarding the structural basis of GPCR function and signalling remain unanswered. The primary outcome of this project is to provide mechanistic insight into the dynamics of GPCR ligand recognition and activation to advance our understanding of GPCR signal transduction, a fundamental biological process for all living organisms.