Research and Mentoring in the Clinical Epidemiology of Cardiovascular Disease and Type 2 Diabetes

心血管疾病和2型糖尿病是主要的公共卫生问题，特别是在老年人中。 我们对糖尿病以及如何预防其相关的微血管和血管疾病的知识存在重大差距 心血管并发症。在老年人中，关于相关风险的总负担存在争议。 糖尿病和糖尿病前期，最佳治疗目标，以及如何最好地降低心血管风险和 防止认知和身体损伤。新的心脏生物标志物反映急性和慢性心肌梗死的总和 慢性发病率，可能对糖尿病和其他心脏代谢性疾病的治疗决定有帮助 条件，但它们没有得到严格的评估。为了解决这些问题，我们需要初级病人- 在临床流行病学领域需要严格培训和指导的定向调查人员， 翻译研究方法，以及进行大型临床研究。候选人伊丽莎白·塞尔文博士， 公共卫生硕士，致力于2型糖尿病和心血管疾病的临床流行病学研究。 疾病和这一领域实习生的指导。这项K24奖励的延续将保护 研究和指导的候选人。本次颁奖的目标是招募一支多元化、多元化的团队。 将接受心血管临床流行病学指导的学科初级调查人员 疾病和糖尿病；促进流行病学和临床研究方法的正式培训 临床医生研究人员；并指导受训人员解决该领域的重要研究问题并帮助 开始他们的独立研究事业。塞尔文博士庞大的研究投资组合(包括三笔R01拨款) 将为学员提供丰富的培训基础和新的研究机会。塞尔文博士有很强的 在该领域和指导初级科学家方面取得成功的记录。在K24的持续支持下，她 将能够扩大她的指导活动，加强她的研究组合，并招募和培训下一位 该领域的一代领导者。

Cardiovascular disease and type 2 diabetes are major public health concerns, particularly in older adults. There are major gaps in our knowledge about diabetes and how to prevent its associated microvascular and cardiovascular complications. In older adults, there is controversy regarding the total burden of risk associated with diabetes and prediabetes, optimal treatment targets, and how best to reduce cardiovascular risk and prevent cognitive and physical impairment. Novel cardiac biomarkers reflect the summation of acute and chronic morbidity and may have utility for informing treatment decisions in diabetes and other cardiometabolic conditions, but they have not been rigorously evaluated. To address these issues, we need junior patient- oriented investigators who will need rigorous training and mentorship in the areas of clinical epidemiology, translational research methods, and the conduct of large clinical studies. The candidate, Elizabeth Selvin, PhD, MPH, has devoted her career to the study of the clinical epidemiology of type 2 diabetes and cardiovascular disease and the mentorship of trainees in this field. The continuation of this K24 award will protect the time of the candidate for research and mentoring. The goals during this award are to recruit a team of diverse, multi- disciplinary junior investigators who will receive mentorship in the clinical epidemiology of cardiovascular disease and diabetes; to promote formal training in epidemiology and clinical research methods for beginning clinician investigators; and to mentor trainees to address significant research questions in the field and help launch their independent research careers. Dr. Selvin's large research portfolio (including three R01 grants) will provide a rich substrate for training and new research opportunities for mentees. Dr. Selvin has a strong track record of success in the field and in mentoring junior scientists. With continued support from this K24, she will be able to expand her mentorship activities, strengthen her research portfolio, and recruit and train the next generation of leaders in the field.