Cancer Prevention and Control

摘要 芝加哥大学医学院癌症预防与控制项目的总体目标 综合癌症中心（UCCCC）通过以下方式促进新的癌症人群科学发现： 跨学科研究的重点是癌症风险和预防的主题，结果和 生存，并将知识转化为临床和公共卫生实践。这一目标将 通过以下具体目标实现：1）应用人口研究方法， 生物，环境和行为因素，有助于癌症的风险，从而增加 预防和早期发现癌症; 2）通过以下措施改善癌症患者的预后和生存率 确定重要的经济和社会心理问题，设计和实施干预措施， 解决这些问题; 3）通过组织方案和主题，促进跨学科的互动 工作组会议，支持试点项目和塑造UCCCC共享资源，并利用 其他机构的研究资源; 4）评估我们的集水区的需求，以告知开展 与这些需求相关的研究和干预措施;以及5）促进和协调培训和指导 各级学生，研究员和初级教师，以培养下一代癌症人群的健康 科学家CPC计划，有来自11个部门和两个部门（生物部门）的38名成员 科学和社会科学），是大多数流行病学和癌症控制的所在地， UCCCC的预防研究。计划成员，其工作可归类为科学 癌症风险和预防以及结果和生存率的主题是UCCCC的主要举措 战略领域，如地方和全球健康差距、遗传流行病学、生存率和癌症 经济学，并促进UCCCC研究计划的人口研究。在目前的资金 在2013-2016年期间，项目成员发表了510篇以癌症为重点的论文（20%在项目内，26%在项目内）， 64%是机构间的）。2016年，我们的计划成员获得了480万美元的支持 （直接成本）在同行评审的资金，包括122万美元从NCI，260万美元在其他NIH 此外，还有308万美元（直接费用）未经同行审议的资金。重要的是，该计划提供 通过我们当地社区的合作努力，评估和传播癌症控制活动， 与UCCCC的社区参与和癌症差异办公室（OCECD）合作， 减少或消除癌症差异是一个总体目标，也是所有这些领域的交叉主题。 活动在UCCCC的支持下，中国共产党成员建立了芝加哥多种族预防和 监测研究（COMPASS）-美国中西部第一个基于人口的城市多种族队列-和 领导了确保NIH资助的伊利诺伊州精准医学联盟的努力。这些举措将共同 在未来几年内，该研究所将对增强癌症人群研究组合产生持久的影响。

ABSTRACT The overall goal of the Cancer Prevention and Control (CPC) Program of the University of Chicago Medicine Comprehensive Cancer Center (UCCCC) is to promote novel cancer population science discoveries through interdisciplinary research focused on the themes of Cancer Risk and Prevention, and Outcomes and Survivorship, and to translate the knowledge into clinical and public health practice. This goal will be accomplished by the following Specific Aims: 1) To apply population research approaches to identify the biological, environmental and behavioral factors that contribute to cancer risk, thereby augmenting the prevention and early detection of cancer; 2) To improve outcomes and survivorship for cancer patients by identifying important economic and psychosocial issues, and designing and implementing interventions that address these issues; 3) To foster transdisciplinary interactions by organizing programmatic and thematic Working Group meetings, supporting Pilot Projects and shaping UCCCC Shared Resources, and leveraging other institutional research resources; 4) To assess the needs of our catchment area to inform the conduct of research and interventions relevant to these needs; and 5) To facilitate and coordinate training and mentorship of students at all levels, fellows, and junior faculty to grow the next generation of cancer population health scientists. The CPC Program, with 38 members from 11 Departments and two Divisions (Divisions of Biological Sciences and Social Sciences), is the home to the majority of epidemiological and cancer control and prevention research for the UCCCC. Program members, whose work can be categorized into Scientific Themes of Cancer Risk and Prevention, and Outcomes and Survivorship, are leading initiatives in UCCCC strategic areas, such as local and global health disparities, genetic epidemiology, survivorship, and cancer economics, and fostering population research across UCCCC Research Programs. In the current funding period (2013-2016), Program members published 510 cancer-focused papers (20% intraprogrammatic, 26% interprogrammatic, and 64% interinstitutional). In 2016, our Program members were supported by $4.8 million (direct costs) in peer-reviewed funding, including $1.22 million from the NCI, and $2.6 million in other NIH support, as well as $3.08 million (direct costs) in non-peer-reviewed funding. Importantly, the Program provides evaluation and dissemination of cancer control activities through collaborative efforts in our local community in collaboration with the UCCCC’s Office of Community Engagement and Cancer Disparities (OCECD), as reducing or eliminating cancer disparities is an overarching goal and cross-cutting theme across all of these activities. With support from UCCCC, CPC members established the Chicago Multiethnic Prevention and Surveillance Study (COMPASS) – the first population-based urban multiethnic cohort in the US Midwest - and led efforts to secure the NIH-funded Illinois Precision Medicine Consortium. Together, these initiatives will have lasting impact on enhancing the cancer population research portfolio at the institution for years to come.