Administrative Core

项目摘要 这个拟议的U19计划项目（PPG）是开创一个多学科的综合/新颖的方法， 多组学数据的综合性trans-omics分析，用于研究骨质疏松症风险的（表观）遗传基础， 男性。为了确保项目规划小组的顺利运作，这一行政核心是必要的，其目标是 提供强有力的领导（在研究，教育和服务），互动和 协作努力、有效的管理（人事和预算）支持以及有效促进 PPG的运作。该核心将发挥协同作用，促进信息交流与合作， PPG内的单个项目/核心，以及PPG研究者与PPG外的研究者。供所有人使用 其他PPG组件，核心将是我们当地研究和指导活动的一个组成部分， 机构研究中心，以产生有效和具有成本效益的管理和人力资源的使用。 该核心包括主任邓博士、副主任戴宁格博士和助理主任沈博士， 有经验。他们将共同提供强大的行政，管理和领导能力， 通过以下活动确保PPG的顺利运作和最大生产力： ·提供及时有效的行政服务 ·协调PPG项目、核心和人员的工作 ·加强与NIH工作人员和科学家的对话，加强与内部的合作关系 和外部咨询委员会以及各部门和机构的同事 ·提供进展和生产力评估以及正在进行的研究的内部质量控制 ·将PPG参与的好处扩展到初级教师，博士后研究员和学生的指导 ·在当地和国家/国际层面协调科学讲座和互动演示 ·组织研究和科学活动及会议，并举办与下列方面有关的科学专题讨论会： PPG研究主题 ·提供支持，例如，预算规划和审查，编写赠款报告和手稿 ·确保遵守领导期望、政府政策和机构指令 ·协调PPG和其他地方/NIH资助项目的实施 ·提供和监测PPG内/外数据共享，以促进研究和数据挖掘 核心服务的使用将在实践中进行微调，主要取决于1） 被认为与核心目标和具体目标相关的其他单个项目/核心，以及2）协调 与其他U19 PPG调查员的董事。核心服务的质量将主要根据 内部反馈和自我审查/评估，并在必要时根据以下方面进行衡量和改进： 内部/外部咨询委员会的反馈和建议。

PROJECT SUMMARY This proposed U19 program project (PPG) is to pioneer a comprehensive/novel approach of multidisciplinary integrative trans-omics analyses of multi-omics data for studying the (epi-)genetic basis of osteoporosis risk for males. To ensure smooth functioning of the PPG, this Administrative Core is necessary, with the Objectives to provide strong leadership (in research, education, and service), productive coordination of interactive and collaborative effort, effective managerial (personnel and budgetary) support, and efficient facilitation for the overall operation of the PPG. The Core will serve as a synergizer to foster information exchange and collaboration, for individual projects/cores within the PPG, and for PPG investigators with those outside the PPG. To be used by all the other PPG components, the Core will be an integrated part of the research and mentoring activities at our local institutional research center, to yield efficient and cost-effective use of management and personnel resources. This core includes Director, Dr. Deng, Associate Director, Dr. Deininger, and Assistant Director, Dr. Shen, all are experienced. They together will furnish strong administrative, management and leadership capabilities for ensuring smooth functioning and maximum productivity of the PPG, through the following activities: • Delivering competent and timely administrative services • Coordinating the efforts of the PPG projects, cores, and personnel • Strengthening dialogue with NIH staff and scientists, enhancing collaborative relationship with the Internal and External Advisory Boards and with colleagues across departments and institutions • Providing progress and productivity evaluation and internal quality control of ongoing research • Extending the benefits of PPG participation to mentoring of junior faculty, postdoctoral fellows, and students • Coordinating scientific lectures and interactive presentations locally and at national/international levels • Organizing research and scientific activities and meetings, and developing scientific symposiums relevant to the PPG research theme • Providing support for, e.g., budgetary planning and review, preparation of grant reports and manuscripts • Assuring compliance with leadership expectations, governmental policies and institutional directives • Coordinating implementation of the PPG and other local/NIH funded projects • Providing and monitoring within-/outside-PPG data sharing for facilitation of the research and data mining The use of the Core services will be, subject to fine-tunes in practice, largely determined by 1) the need of the other individual projects/cores as deemed relevant to the Core’s Objectives and Specific Aims, and 2) coordination of the Directors with other U19 PPG investigators. The quality of the Core services will be measured mainly based on the internal feedbacks and self-review/evaluation, and also be measured and improved if necessary based on the feedbacks and recommendations from the In-/Ex-ternal Advisory Boards.