The Lung PCA: A Multi-Dimensional Atlas of Pulmonary Premalignancy

在本提案中，为了加强正在进行的肺PCA研究，我们提出旨在研究肺癌发展各个阶段中关键SARS-CoV-2病毒进入基因的蛋白定位、细胞类型特异性表达和上调的生物学途径。我们将把这些结果与COVID-19死亡患者肺组织中关键SARS-CoV-2病毒进入基因以及免疫、上皮和内皮细胞蛋白的蛋白表达进行比较，这些蛋白表达来自COVID-19前和后疾病的肺组织样本。研究中心气道和肺泡肺癌发展过程中上皮和间质微环境的空间特征以及关键SARS-CoV-2进入基因的表达，可能为改善这一高危患者群体的临床管理和改善COVID-19结局找到潜在的途径

In this proposal, that enhances ongoing Lung PCA studies, we propose aims to examine the protein localization, cell type specific expression, and biological pathways up-regulated with key SARS-CoV-2 viral entry genes across the various stages of lung cancer development. We will compare these results with protein expression of key SARS-CoV-2 viral entry genes as well as immune, epithelial, and endothelial cell proteins in lung tissue from patients that died from COVID-19, and from lung tissue sampled pre- and post-COVID-19 disease. Spatially characterizing the epithelium and stromal microenvironment and expression of key SARS-CoV-2 entry genes during the development of lung cancer in the central airway and the alveoli may identify potential ways to improve clinical management of this high-risk patient population and improve COVID-19 outcomes