Harnessing the power of experimental genetic crosses and systems genetics to probe drug resistance in malaria

摘要 总部设在圣母大学的行政核心(行政核心)将确保 方案项目赠款(P01)PI和行政核心主任(AD)(费迪格)的职位是监督和 管理P01。管理核心将促进所有小组之间的沟通和互动，并将 从而确保这三个物理上分离的站点将作为一个虚拟的单个站点运行。AD，在协助下 来自行政核心项目经理(PM)，将负责协调整个科学方向，并将 监控P01的持续生产力，并将活动传达给咨询委员会。在ITS中 管理能力，管理核心将集中整个计划的信息，提供管理 支持项目调查人员，并维护与P01进度相关的记录。费迪格将参与并 管理所有级别的沟通，负责所有方面的有效运营和 与领导团队(LT)进行协作决策。 助理总干事将在一名项目经理和由所有项目负责人和核心主管组成的助理总干事的协助下， 集中整个计划的信息并协调P01的总体方向和反馈的功能 来自内部咨询委员会(IAB)和外部咨询委员会(EAB)。IAB将评估正在进行的 实现P01目标的进展情况，并为P01活动的替代战略提供建议，如果 指出了修改意见。IAB的成员将由三个国家的杰出专家教员组成 表演网站(UND、德克萨斯生物学院和CID Research)。EAB将指导和评估整体 该计划的影响和生产力与更广泛的科学界在以下领域保持一致 P<0.01。EAB将与NIH计划顾问进行沟通，并将由世界各地的 经典遗传学、连锁图谱、系统生物学、疟疾和抗药性方面的专家。

ABSTRACT The Administrative Core (Admin Core) based at the University of Notre Dame (UND) will ensure that the Program Project grant (P01) PI and Admin Core Director (AD)(Ferdig) is positioned to supervise and administer the P01. The Admin Core will facilitate communication and interaction between all groups and will thus ensure that the three physically separate sites will function as a virtual single site. The AD, with assistance from the Admin Core Program Manager (PM), will function to coordinate the overall scientific direction and will monitor ongoing productivity of the P01 and communicate the activities to the Advisory Boards. In its administrative capacity, the Admin Core will centralize program-wide information, provide administrative support to program investigators, and maintain records relating to P01 progress. Ferdig will participate and manage at all levels of communication and is responsible for all aspects of effective operations and collaborative decision-making with the Leadership Team (LT). The AD, with the assistance of a PM and the LT, consisting of all Project Leads and Core Directors, will function to centralize program-wide information and to coordinate the overall direction of the P01 with feedback from an Internal Advisory Board (IAB) and an External Advisory Board (EAB). The IAB will evaluate ongoing progress towards P01 goals and provide recommendations for alternative strategies to P01 activities if modifications are indicated. Members of the IAB will consist of distinguished expert faculty at the three performance sites (UND, Texas Biomed and CID Research). The EAB will guide and evaluate the overall impact and productivity of the program in alignment with the broader scientific community in the areas of the P01. The EAB will be formed in communication with NIH Program advisors and will consist of worldwide experts on classical genetics, linkage mapping, systems biology, malaria and drug resistance.