Midcareer Mentoring in Patient-Oriented Research on Genitourinary Aging in Women

项目总结 此次申请K24职业中期调查员奖将促进艾莉森·黄博士的指导和 以病人为导向的女性泌尿生殖系统老化研究中的职业发展。黄博士是一位将军 致力于促进科学理解和改进的内科医生和妇女健康调查员 管理老龄化对妇女健康的影响，特别是对生殖健康的影响。有了来自 国家老龄研究所和其他NIH研究所/中心，她领导着一位全国公认的患者- 以研究为导向的计划，强调与衰老相关的生殖泌尿系统的共同因素 功能障碍和其他常见的衰老综合征，如身体功能下降，认知能力下降， 抑郁和焦虑，以及睡眠障碍。到目前为止，她的工作已经创造了新的患者报告结果 在国内和国际老年妇女生殖健康研究中使用的措施，并提供了 指导尿失禁等疾病诊断和治疗策略的新证据， 泌尿生殖器萎缩、夜尿和更年期症状。她还成为了一位成功的 发表了高影响力研究，获得联邦资助的研究奖的初级临床医生，以及 继续参与以病人为导向的老年妇女健康研究。 目前，国家老龄研究所还没有为研究提供指导的K24奖项 对女性的生殖泌尿系统老化或对老年妇女的健康有广泛影响。因此，黄博士寻求支持 扩大她对各种临床实习生的指导，这些学员对研究泌尿生殖健康和功能感兴趣 对老年妇女的影响以及老龄化和更年期对老年妇女健康的影响。她会利用 过去和现在的研究项目提供了丰富的与衰老相关的尿液和尿液数据 阴道症状、与年龄相关的身心功能变化以及相关的生活质量 居住在社区的老年妇女。她将回答有关两国关系的新研究问题。 尿失禁、体能、心理功能和睡眠质量的变化 老年妇女对基于行为、体力活动的干预的反应，使用辅助手段 她最近启动的一项临床试验中包含了一些措施。她将开发一个新的车间 旨在指导早期调查人员设计和进行试点或可行性试验的系列。她 还将实施正式的指导计划，包括招聘、发展和评估 来自不同背景的其他学员。这些计划将充分利用优秀的研究成果。 加州大学旧金山分校的培训环境和利用黄博士已经担任过的多个领导职位 美国国立卫生研究院资助的培训计划，以确定和支持有潜力成为 在老龄化和妇女健康的交叉点上，以病人为导向的研究的领导者。

PROJECT SUMMARY This application for a K24 Midcareer Investigator Award will promote Dr. Alison Huang’s mentoring and career development in patient-oriented research on genitourinary aging in women. Dr. Huang is a general internist and women’s health investigator dedicated to advancing scientific understanding and improving management of the impact of aging on women’s health, especially genitourinary health. With funding from the National Institute on Aging and other NIH institutes/centers, she leads a nationally recognized, patient- oriented research program that emphasizes shared factors underlying aging-associated genitourinary dysfunction and other common aging syndromes such as physical function decline, cognitive decline, depression and anxiety, and sleep disruption. Her work to date has created new patient-reported outcome measures used in national and international studies of genitourinary health in older women and provided new evidence to guide diagnostic and treatment strategies for conditions such as urinary incontinence, urogenital atrophy, nocturia, and menopausal symptoms. She has also emerged as a successful mentor of junior clinicians who have published high-impact research, obtained federally funded research awards, and continued to participate in patient-oriented research on older women’s health. Currently there are no K24 awards from the National Institute on Aging that support mentorship for research on genitourinary aging in women or on older women’s health broadly. As a result, Dr. Huang seeks support to expand her mentoring of diverse clinical trainees interested in studying genitourinary health and function in older women as well as the impact of aging and menopause on older women’s health. She will leverage past and current research projects that contribute a rich repository of data on aging-related urinary and vaginal symptoms, aging-related changes in physical and mental function, and associated quality of life in older community-dwelling women. She will address new research questions about relationships between changes in urinary incontinence, physical performance, psychological function, and sleep quality and disruption in older women in response to behavioral, physical activity-based interventions, using ancillary measures incorporated into one of her recently launched clinical trials. She will develop a new workshop series designed to guide early stage investigators in designing and conducting pilot or feasibility trials. She will also carry out a formal mentoring program with plans for recruitment, development, and evaluation of additional mentees from diverse backgrounds. These plans will make full use of the outstanding research training environment at UCSF and leverage leadership positions that Dr. Huang already holds in multiple NIH-funded training programs to identify and support high-quality mentees with the potential to become leaders in patient-oriented research at the intersection of aging and women’s health.