CHARACTERIZING AND IMPROVING HUMANIZED IMMUNE SYSTEM MOUSE MODELS (IMM-HIS)

本研究的重点是用mhc定义的猪胎胸腺组织代替人胎胸腺组织构建人免疫系统（HIS）小鼠的能力。本研究探讨了用mhc定义的猪胎胸腺组织代替人胎胸腺组织构建人源化免疫系统（HIS）小鼠的能力。用猪胸腺组织构建的HIS小鼠的T细胞重构和功能将与用脐带血CD34+细胞构建的HIS小鼠进行比较，然后尝试用转基因猪的常见HLA等位基因来改善猪胸腺的重构和功能。

The study focuses on the ability to substitute MHC-defined porcine fetal thymus tissue for human fetal thymus tissue for the construction of human immune system (HIS) mice. The study explores the ability to substitute MHC-defined porcine fetal thymus tissue for human fetal thymus tissue for the construction of humanized immune system (HIS) mice. T cell reconstitution and function in HIS mice constructed with fetal pig thymic tissue will be compared to mice HIS mice constructed from cord blood CD34+ cells, followed by an attempt to improve reconstitution and function by porcine thymus by using pigs that are transgenic for common HLA alleles.