Informing national guidelines on adolescent and young adult physical activity and sedentary behavior to prevent cardiovascular disease

项目总结/摘要 心血管疾病（CVD）是美国死亡的主要原因，体力活动是一种有效的方法。 降低这种风险的方法。我们对身体活动的最佳持续时间的理解仍然存在严重差距 以及青少年和青年期久坐不动的行为， 避免，并被特别确定为2018年卫生和人类部的优先研究领域 服务（HHS）美国人的身体活动指南。青春期和青年期至关重要 过渡期为成年期的其余部分设定了身体活动模式，可能代表了一个关键的窗口 进行早期干预。本K 08的总体目标是开发证据，以弥合HHS-关节间隙 通过描述青少年久坐行为的独立影响和青少年体力活动的阈值， 年轻人对预防晚年CVD的影响，以告知未来的HHS指南。核心假设是 高度久坐的青少年和年轻人需要更高的体力活动水平来降低CVD风险 在成年后期。该项目将分析来自青少年大脑认知研究的纵向队列数据。 发展（ABCD）研究，青少年到成人健康（添加健康）的国家纵向研究，以及 年轻人冠状动脉风险发展（CARDIA）研究。具体目标：（1）确定 CVD青少年中当代形式久坐行为（屏幕时间）的独立关联 危险因素发生率;（2）评估达到HHS推荐的青少年（60分钟/天，7 每天/周）与成人（30分钟/天，5天/周）在特定年龄范围内的体力活动水平， 成年期CVD危险因素的发病率;（3）估计青少年和 年轻人久坐行为、体力活动剂量及其对晚年CVD死亡率的相互作用。的 候选人的长期职业目标是成为一名独立的流行病学医生， 可采取行动的证据，以优化青少年和年轻人的行为，以防止CVD在以后的生活。拟议 职业发展计划将提供以下方面的培训和指导：（1）身体活动，久坐行为， CVD流行病学和测量;（2）纵向分析和建模方法;（3）指南 开发与实施;（4）职业发展与独立计划。培训将 通过课程、研讨会、辅导、会议、实践经验和积极的指导来实现。的 指导团队包括国家认可的心血管流行病学专家，青少年和年轻人 成人医学、体力活动/久坐行为、生物统计学、指南制定和实施 科学本K 08的完成将在下一版中为青少年和年轻人提供具体指导 《美国人体育活动指南》K 08将支持未来的R 01赠款， 科学和建模方法，以促进实现国家体育活动指南，以预防心血管疾病， 与NHLBI通过数据和实施科学减少心脏病的战略愿景保持一致。

PROJECT SUMMARY / ABSTRACT Cardiovascular disease (CVD) is the leading cause of death in the United States and physical activity is a potent way to decrease this risk. Serious gaps remain in our understanding of the optimal duration of physical activity and sedentary behavior during adolescence and young adulthood if risk for concurrent and future CVD is to be averted, and were specifically identified as priority research areas in the 2018 Department of Health and Human Services (HHS) Physical Activity Guidelines for Americans. Adolescence and young adulthood are critical transition periods that set physical activity patterns for the rest of adulthood and may represent a critical window for early intervention. The overall objective of this K08 is to develop evidence to bridge the HHS-articulated gaps by describing independent effects of sedentary behavior in adolescence and thresholds of physical activity in young adulthood on the prevention of later-life CVD to inform future HHS guidelines. The central hypothesis is that highly sedentary adolescents and young adults will require higher physical activity levels to reduce CVD risk in later adulthood. This project will analyze longitudinal cohort data from the Adolescent Brain Cognitive Development (ABCD) Study, the National Longitudinal Study of Adolescent to Adult Health (Add Health), and the Coronary Artery Risk Development in Young Adults (CARDIA) Study. The Specific Aims will: (1) determine independent associations of contemporary forms of sedentary behavior (screen time) in adolescents with CVD risk factor incidence; (2) evaluate associations of attaining HHS-recommended adolescent (60 mins/day, 7 days/week) versus adult (30 mins/day, 5 days/week) physical activity levels during specific age ranges in young adulthood with incidence of CVD risk factors; and (3) estimate population-level lifetime effects of adolescent and young adult sedentary behaviors, physical activity dose, and their interactions on later-life CVD mortality. The candidate’s long-term career objective is to become an independent physician-epidemiologist generating actionable evidence to optimize adolescent and young adult behaviors to prevent CVD later in life. The proposed career development plan will provide training and mentorship in: (1) physical activity, sedentary behavior, and CVD epidemiology and measurement; (2) longitudinal analyses and modeling methods; (3) guideline development and implementation; and (4) career development and plan for independence. Training will be achieved through coursework, seminars, tutorials, conferences, hands-on experience, and active mentoring. The mentoring team includes nationally recognized experts in cardiovascular epidemiology, adolescent and young adult medicine, physical activity/sedentary behavior, biostatistics, guideline development, and implementation science. Completion of this K08 will inform specific guidance for adolescents and young adults in the next edition of the Physical Activity Guidelines for Americans. The K08 will support a future R01 grant using implementation science and modeling approaches to promote attainment of national physical activity guidelines to prevent CVD, aligned with NHLBI’s strategic vision of reducing heart disease through data and implementation science.