AACR Special Conference on Colorectal Cancer

摘要 拟召开的题为“结直肠癌”的会议将于2021年10月21日至24日在 明尼苏达州明尼阿波利斯。这将是AACR第二次专门关注 近5年来结直肠癌的研究进展。结直肠癌(CRC)是第二大癌症 是美国癌症死亡的主要原因。不利的风险因素，如肥胖， 缺乏体育活动和吸烟，再加上人口老龄化和饮食习惯高- 收入国家增加了CRC的风险。年结直肠癌发病率和死亡率也在上升。 年轻发病人群中，约12%的病例是在50岁以下的个人中确诊的。 病理生理学理解的进步增加了治疗选择的阵列 用于局部和晚期疾病，导致个体化治疗计划，尽管目前的治疗方法 已经导致了结直肠癌发病率和死亡率的总体下降， 晚期转移性结直肠癌患者约占14%。结直肠癌的发病率和死亡率 通过适当的筛查和监测来缓解，但其有效性是 受到几个因素的危害，包括缺乏可及性和次优筛选 合规性。这些数据突显出迫切需要继续研究以改进诊断 检测和治疗范例。其目的是将基础研究和翻译研究联系起来 临床护理方面，拟议的会议将把研究科学家和临床医生聚集在一起 讨论CRC研究的最新发现。为此，AACR正在寻求支持，以扩大 会议，并通过额外的学者招募优秀的年轻研究人员- 训练奖。这一“下一代”癌症科学家和照顾者的出席将有所帮助 更好地传播快速增长的研究创新集合，并点燃新的 合作。该节目经过精心设计，以发人深省的会议为特色 关于危险因素和预防、基因组学、微生物组、免疫治疗等方面的进展 新兴疗法。合作和联网也将通过以下方式得到鼓励 与会者之间进行深思熟虑的讨论和有意义的互动的多个机会。

ABSTRACT The proposed conference, entitled “Colorectal Cancer” will be held October 21-24, 2021 in Minneapolis, Minnesota. This will be the second AACR conference focused specifically on advances in colorectal cancer held in the last 5 years. Colorectal cancers (CRC’s), are the second leading cause of cancer deaths in the United States. Unfavorable risk factors such as obesity, physical inactivity, and smoking in addition to an ageing population and dietary habits of high- income countries increases the risk of CRC. CRC incidence and mortality rates are also rising in the young-onset population, with ~12% of cases being diagnosed in individuals under age 50. Advancements in pathophysiological understanding have increased the array of treatment options for local and advanced disease leading to individual treatment plans Although current therapies have led to an overall decrease in CRC incidence and mortality, the 5-year survival rate for patients with advanced metastatic CRC stands at about 14%. CRC morbidity and mortality can be mitigated through appropriate screening and surveillance however its effectiveness is jeopardized by a several factors including the lack of accessibility and suboptimal screening compliance. These data highlight the acute need for continued research to improve diagnostic testing and treatment paradigms. With the aim of connecting basic and translational research to clinical care, the proposed conference will bring together research scientists and clinicians to discuss the latest findings in CRC research. To this end, the AACR is seeking support to expand the conference and to recruit outstanding young investigators through additional Scholar-in- Training awards. Attendance by this “next generation” of cancer scientists and caregivers will help better disseminate the rapidly growing collection of research innovations as well as ignite new collaborations. The program has been carefully designed to feature thought-provoking sessions on advances in risk factors and prevention, genomics, microbiome, immunotherapy, and other emerging therapies. Collaboration and networking will also be encouraged by incorporating multiple opportunities for thoughtful discussion and meaningful interaction between participants.